Glycation impairs high-density lipoprotein function
نویسندگان
چکیده
منابع مشابه
High-Density Lipoprotein Function
Although high-density lipoproteins (HDL) possess many features that contribute to the association between elevated HDL cholesterol and protection from atherosclerosis, these lipoproteins may be modified in certain individuals and/or circumstances to become proinflammatory. The ability of HDL to inhibit or paradoxically to enhance vascular inflammation, lipid oxidation, plaque growth, and thromb...
متن کاملThe role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases
High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationshi...
متن کاملHigh density lipoprotein--quality and function.
Introduction Atherosclerosis is a focal disease of the large and medium sized arteries in areas of disturbed blood flow caused by endothelial injury, dysfunction and local inflammation [1]. Coronary heart disease (CHD) is the most common cause of death in western countries and in developing countries it accounts for over 4.5 million deaths annually [2]. Dyslipidaemia has been identified as a ma...
متن کاملGlycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides
AIMS High-density lipoprotein (HDL) protects against atherosclerosis development. Defective functioning of HDL in Type 2 diabetes may be one cause of increased cardiovascular disease associated with Type 2 diabetes. HDL modulates low-density lipoprotein and cell membrane oxidation through the action of paraoxonase-1 (PON1), which is one of the major mechanisms by which HDL is anti-atherogenic. ...
متن کاملInfluence of Flavonols As in vitro on Low Density Lipoprotein Glycation
The non-enzymatic glycation of Low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and glucose. Glycated LDL is poorly recognized by LDL receptors and initiates different processes that can be considered proatherogenic. Thus, LDL glycation may contribute in the increased atherosclerotic risk of pati...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2000
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250050049